Enhancing anti-tumor immune responses in colon cancer metastases

LIGHT expressing tumors generated increased T-cell proliferation, a tumor-specific anti-tumor immune response, and significant T-cell mediated tumor regressions (C) CT26LIGHTi colon cell tumors were established in animals fed normal diet (n=18) and once palpable and measurable, randomized on day 6 (arrow) to doxycycline diet (LIGHT induction) or normal diet. Significant tumor regression began only in animals with LIGHT induction and continued with partial and complete tumor responses as measured by total tumor volume, WHO criteria, and RECIST clinical tumor response criteria (pictured). Graph provided by: Ajay Maker