Nanostructures as Antibacterial Agents
Date / Time
April 3, 2019 - April 3, 2019
3:30 pm - 4:30 pm
Role of Supramolecular Morphology in Biological Action
Seminar given by Martin Conda-Sheridan, Ph.D.
Dept. of Pharmaceutical Sciences
University of Nebraska Medical Center
Abstract: The development of bacterial resistant strains to traditional antibiotics is a global health concern. Designing new antibacterial agents is essential to fight this serious thread. In this seminar, I will describe the potential of nanostructures made of cationic peptide amphiphiles (PAs) as new entities to deal with bacterial infections. I will show the antimicrobial action of the nanostructures against gram-positive, and gram-negative bacteria, and against mammalian cells. I will also discuss the effect that supramolecular morphology has on antimicrobial action. I will describe the key parameters to design better antimicrobials. Finally, I will present the mechanism of action of the new entities and future directions of the project.