KralHan_4x6

January 27, 2021

Double-faced peptide-based boosters are computationally designed to allow recognition of SARS-CoV-2

Double-faced peptide-based boosters are computationally designed to allow recognition of SARS-CoV-2 (grey, schematic) by Hepatitis B antibodies. One booster face made of ACE2-mimic peptides (red) can bind to the receptor binding domain of SARS-CoV-2 (blue). The other booster face composed of a Hepatitis B core-antigen (orange) can target the Hepatitis B antibody fragment (green). This approach can provide a cheap and efficient neutralization of emerging pathogens by generic antibodies.

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