Jeffrey Loeb

Professor and Head of Neurology and Rehabilitation


Jeffrey Loeb; experts guide

Dr. Jeffrey Loeb — Photo: Jenny Fontaine

Dr. Jeffrey Loeb is the John S. Garvin Endowed Chair in Neurology and professor and head of neurology and rehabilitation in the UIC College of Medicine.

As a clinician, Loeb specializes in the evaluation and treatment of epilepsy. He is an expert in the measurement and assessment of epileptic electrical activity in the brain using EEG, or electroencephalography, and in the medical and surgical management of patients with hard-to-control seizures.

Loeb has pioneered a unique systems-biology approach to diagnose and treat disease by analyzing gene and protein expression in the brain and spinal cord. This technique has revealed previously unknown ‘micro-lesions’ in the brain tissue of patients with neocortical epilepsy. He is now using the same approach to investigate ALS and several potential treatments for ALS, multiple sclerosis, pain, spinal cord injury, brain cancers and Alzheimer’s disease.

In 2017, Loeb established the University of Illinois NeuroRepository in the UIC College of Medicine, which collects tissue samples from patients treated for neurological disorders at the University of Illinois Hospital. Each specimen will be linked to clinical, radiological, electrical, histological and genetic information – “big data” that requires advanced computing hardware and software to store and query.

Loeb is also a leading researcher in growth-factor signaling in motor neurons, and he has developed a patented drug-targeting technology that could significantly improve the treatment of brain disorders and cancer.

Loeb is a member of the American Academy of Neurology, the American Epilepsy Society, the Society for Neuroscience, and the American Neurological Association. He is on the professional advisory board of the Epilepsy Foundation of America and is a regular member of the NIH’s developmental neuroscience study section.

Subject areas:

  • Epilepsy
  • Electroencephalography (EEG)
  • Sturge-Weber Syndrome
  • ALS
  • Multiple sclerosis
  • Alzheimer’s disease
  • Genetics of neurological disorders
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